Histologic Variants of Fibrous Papule
Identifieur interne : 008364 ( Main/Exploration ); précédent : 008363; suivant : 008365Histologic Variants of Fibrous Papule
Auteurs : C. Bansal [États-Unis] ; D. Stewart [États-Unis] ; A. Li [États-Unis] ; C. Cockerell [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Fibrous papule (FP), synonymous with angiofibroma, is a common lesion that is often biopsied to exclude carcinoma. Clinically, FPs are small, dome‐shaped, solitary, flesh colored papules arising on the nose and face of adults. Histologically, FPs are characterized by a dome‐shape, fibrotic collagenized stroma, sparse inflammatory cell infiltrate, and variably increased and dilated vascular spaces. The vast majority of FPs are readily diagnosable based on these clinical and histologic criteria. Rare histopathologic variants have been reported. Recognition of these variants may avoid misdiagnosis of this common benign lesion. We illustrate four rare variants of FP that can cause diagnostic uncertainty including: hypercellular, clear cell, pigmented, and pleomorphic variants. Cellular FP has a dense infiltrate of round fibroblasts that have a nevoid appearance. Clear cell FP has a proliferation of round clear cells, some with slightly foamy cytoplasm, resembling histiocytes or clear epithelial cells. Pleomorphic FP demonstrates bizarre, stellate fibroblasts like those seen in pleomorphic fibroma. Pigmented FP has prominent melanocytic hyperplasia and dermal melanophages that can be confused with a melanocytic lesion. It is important to recognize these unusual variants of FP in order to accurately diagnose this common benign lesion and avoid over treatment or rebiopsy.
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DOI: 10.1111/j.0303-6987.2005.0320q.x
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Bansal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Stewart, D" sort="Stewart, D" uniqKey="Stewart D" first="D." last="Stewart">D. Stewart</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Li, A" sort="Li, A" uniqKey="Li A" first="A." last="Li">A. Li</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cockerell, C" sort="Cockerell, C" uniqKey="Cockerell C" first="C." last="Cockerell">C. Cockerell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="75">75</biblScope><biblScope unit="page" to="75">75</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fibrous papule (FP), synonymous with angiofibroma, is a common lesion that is often biopsied to exclude carcinoma. Clinically, FPs are small, dome‐shaped, solitary, flesh colored papules arising on the nose and face of adults. Histologically, FPs are characterized by a dome‐shape, fibrotic collagenized stroma, sparse inflammatory cell infiltrate, and variably increased and dilated vascular spaces. The vast majority of FPs are readily diagnosable based on these clinical and histologic criteria. Rare histopathologic variants have been reported. Recognition of these variants may avoid misdiagnosis of this common benign lesion. We illustrate four rare variants of FP that can cause diagnostic uncertainty including: hypercellular, clear cell, pigmented, and pleomorphic variants. Cellular FP has a dense infiltrate of round fibroblasts that have a nevoid appearance. Clear cell FP has a proliferation of round clear cells, some with slightly foamy cytoplasm, resembling histiocytes or clear epithelial cells. Pleomorphic FP demonstrates bizarre, stellate fibroblasts like those seen in pleomorphic fibroma. Pigmented FP has prominent melanocytic hyperplasia and dermal melanophages that can be confused with a melanocytic lesion. It is important to recognize these unusual variants of FP in order to accurately diagnose this common benign lesion and avoid over treatment or rebiopsy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Bansal, C" sort="Bansal, C" uniqKey="Bansal C" first="C." last="Bansal">C. Bansal</name></region><name sortKey="Cockerell, C" sort="Cockerell, C" uniqKey="Cockerell C" first="C." last="Cockerell">C. Cockerell</name><name sortKey="Li, A" sort="Li, A" uniqKey="Li A" first="A." last="Li">A. Li</name><name sortKey="Stewart, D" sort="Stewart, D" uniqKey="Stewart D" first="D." last="Stewart">D. Stewart</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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